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May 13, 2014

What is second type diabetes

(See "Patient education: Hypoglycemia (low blood sugar) in diabetes mellitus (Beyond the Basics)". You should stop taking these drugs if you develop severe abdominal pain. 3%) in the placebo, 200mg and 400mg dose arms, respectively. Across all three dose arms (placebo, 200mg, 400mg), the incidence of treatment-emergent adverse events (AEs) were 51. 9% and 3. 2% and 4. They lower blood sugar levels by increasing insulin release from the pancreas in response what is second type diabetes to a meal. The number of patients with DKA events during the 24-week treatment period was none (0. Prior to randomization, insulin was optimized for all patients over a six-week period, with the objective of improving glycemic control using insulin what is second type diabetes alone. They are not a first-line treatment, but they can be given alone in patients who can't tolerate the first-line medicines (metformin, sulfonylureas), or they can be given with other oral medicines if blood sugars are still higher than goal. Changes in diet can improve many aspects of type 2 diabetes, including your weight, blood pressure, and your body's ability to produce and respond to insulin. The number of patients with severe hypoglycemic events during the 24-week treatment period was seven (2. There were two deaths in the study in the placebo arm and no deaths in either sotagliflozin arm. 8%), and six (2. Sotagliflozin has been shown in a Phase 2 study to improve glycemic control in people with type 1 diabetes while reducing their need for mealtime insulin. ) Lexicon is conducting a third Phase 3 clinical trial in type 1 diabetes patients, inTandem3, which is studying approximately 1,400 patients treated with sotagliflozin 400mg once daily or placebo on a background of any insulin therapy, but without insulin optimization prior to randomization. They may be especially helpful for overweight patients who are gaining weight on oral medicine. (See "Patient education: Diabetes mellitus type 2: Insulin treatment (Beyond the Basics)". After completion of this optimization period, patients were maintained on how to treat high blood sugar optimized insulin and randomized to one of two doses of sotagliflozin or placebo, and their baseline, post-optimization A1C was measured. 4%, 55. It is possible to pass out if you do not treat low blood sugar fast enough. 4%, respectively; the incidence of serious AEs (SAEs) were 3. 6%, 1. Dipeptidyl peptidase-4 (DPP-4) inhibitors are expensive, and the long-term risks and benefits are unknown. The double-blind, placebo controlled, Phase 3 study known as inTandem2 randomized 782 adult patients in Europe and Israel with type 1 diabetes on insulin pump or multiple daily injection therapy who had an what to do when your sugar is high A1C why i am so tired level entering the study between 7. what are high blood sugar levels Pancreatitis has been reported rarely in patients taking GLP agonists, but it is not known if the drugs caused the pancreatitis. 7%), ten (3. 4%), and three (1. 71% for patients randomized to the placebo, 200mg and 400mg arms, respectively. Because they are relatively new drugs, long-term risks and benefits are not known. People with type 2 diabetes often feel stress related to their disease and the increased responsibilities that come with diabetes, including blood sugar testing, watching the diet, exercise, doctor visits, the need for medicines, and the potential risks of complications. The overall mean placebo-adjusted what is second type diabetes A1C reduction at week 24 was 0. ) GLP agonists — The glucagon-like peptide (GLP) agonists, exenatide (brand name: Byetta), exenatide extended release (Bydureon), liraglutide (brand name: Victoza), albiglutide (brand name: Tanzeum), dulaglutide (brand name: Trulicity), and lixisenatide (brand name: Adlyxin), are injectable medicines. These medicines do not cause hypoglycemia or changes in body weight. Sanofi how do people get diabetes is responsible for what is second type diabetes conducting the Phase 3 clinical trials for sotagliflozin in patients with type 2 diabetes. (See "Patient education: Type 2 diabetes mellitus and diet (Beyond the Basics)". 0%, respectively. ) The primary endpoint of the study was change in A1C from baseline after a 24-week what is second type diabetes period of treatment. Exenatide what is second type diabetes and lixisenatide should not be used in patients with abnormal kidney function, and liraglutide, dulaglutide, and albiglutide should be used with caution in patients with renal impairment. 001). GLP agonists do not usually cause low blood sugar. 9% and 54. 1%) in the placebo, 200mg and 400mg dose arms, respectively. The trial has cause of type 2 diabetes in adults a double-blind long term extension of 28 weeks, with a total treatment duration of 52 weeks. 74% and 7. 0% and 11. Patient education: Diabetes mellitus type 2: Overview (Beyond the Basics) Patient education: Diabetes mellitus type 2: Insulin treatment (Beyond the Basics) Patient education: Type 2 diabetes mellitus and diet (Beyond what causes diabetes type 2 in adults the Basics) Patient education: Self-blood glucose monitoring in diabetes mellitus (Beyond the Basics) Patient education: Hypoglycemia (low blood sugar) in diabetes mellitus (Beyond the Basics) Patient education: Diabetes mellitus type 2: Alcohol, exercise, and medical care (Beyond the Basics) Patient education: Preventing complications in diabetes mellitus (Beyond the Basics) DPP-4 inhibitors — This class of medicines includes sitagliptin (brand name: Januvia), saxagliptin (brand name: Onglyza), linagliptin (brand name: Tradjenta), alogliptin (brand name: Nesina), and vildagliptin (brand name: Galvus). 001) and how to identify kidney problems 0. However, they may cause some nausea and diarrhea. ” Discovered using Lexicon’s unique approach to gene science, sotagliflozin is a first-in-class, what is second type diabetes oral dual inhibitor of two proteins responsible for glucose regulation relief for sciatica nerve pain known as sodium-glucose co-transporter types 1 and 2 (SGLT1 and SGLT2). 2%, respectively; and discontinuation due to AEs were 1. The mean baseline A1C levels after the six-week optimization period were 7. About Sotagliflozin Sotagliflozin was generally well tolerated. These drugs are more expensive than insulin. “These top-line results confirm the results we announced earlier this year from our first pivotal Phase 3 study of sotagliflozin,” said Lexicon president and chief executive officer, Lonnel Coats. 35% in the 400mg dose arm (p<0. They promote weight loss but can also cause bothersome side effects, including nausea, vomiting, and diarrhea. Low blood sugar must be treated symptons of high blood sugar quickly by eating 10 to 15 grams of fast-acting carbohydrate (eg, fruit juice, hard candy, glucose tablets). 36% in the 200mg dose arm (p<0. 5%, 4. Studies looking to see if there are similar benefits from other GLP agonists are ongoing. A full discussion of low blood sugar is available separately. There were 257 patients in the placebo arm, 261 patients in the 200mg dose arm and 263 patients in the 400mg dose arm. Detailed information about type 2 diabetes and diet is available separately. Vildagliptin is available in Europe but not in the United States. They are not a first-line treatment but might be considered for people whose blood sugar is not controlled on the highest dose of one or two oral medicines. There have been rare reports of pancreatitis and skin reactions. When to add a second medicine — Your doctor or nurse might recommend a second medicine within the first two to three months if your blood sugar levels and glycated hemoglobin (A1C) are still higher than your goal. 0%), one (0. 0%. SGLT1 is the primary transporter for absorption of glucose and galactose in the gastrointestinal tract, and SGLT2 is primarily responsible for glucose reabsorption by the kidney. It is not uncommon to become depressed as a result of this stress, and this can make taking care of yourself more difficult. The three-arm study evaluated two doses of sotagliflozin, 200mg and 400mg, each taken once daily before the first meal of the day, against placebo. Among patients who already have had a heart attack or stroke, liraglutide has been shown to improve cardiovascular disease outcomes. 80%, 7. “We are extremely pleased with the results in both of these Phase 3 studies and are enthusiastic about the potential benefits that sotagliflozin may bring to people with type 1 diabetes. Two primary safety concerns for patients with type 1 diabetes are severe hypoglycemia and diabetic ketoacidosis (DKA).

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